The KISS1 metastasis suppressor: mechanistic insights and clinical utility
نویسندگان
چکیده
منابع مشابه
The metastasis suppressor KISS1 lacks antimetastatic activity in the C8161.9 xenograft model of melanoma.
The objective of this study was to use the established xenograft model of human melanoma (C8161.9) to test a pharmacological approach to the effect of the metastasis suppressor KISS1. A KISS1 analog was used to inhibit the metastatic development of C8161.9 cells in nude mice. Further experiments were performed to test the validity of the C8161.9 model and test the connection between KISS1 expre...
متن کاملMetastasis suppressor KISS1 seems to reverse the Warburg effect by enhancing mitochondrial biogenesis.
Cancer cells tend to utilize aerobic glycolysis even under normoxic conditions, commonly called the "Warburg effect." Aerobic glycolysis often directly correlates with malignancy, but its purpose, if any, in metastasis remains unclear. When wild-type KISS1 metastasis suppressor is expressed, aerobic glycolysis decreases and oxidative phosphorylation predominates. However, when KISS1 is missing ...
متن کاملThe metastasis suppressor KISS1 is an intrinsically disordered protein slightly more extended than a random coil
The metastasis suppressor KISS1 is reported to be involved in the progression of several solid neoplasias, making it a promising molecular target for controlling their metastasis. The KISS1 sequence contains an N-terminal secretion signal and several dibasic sequences that are proposed to be the proteolytic cleavage sites. We present the first structural characterization of KISS1 by circular di...
متن کاملPolymorphisms rs12998 and rs5780218 in KiSS1 Suppressor Metastasis Gene in Mexican Patients with Breast Cancer
AIMS KiSS1 is a metastasis suppressor gene associated with inhibition of cellular chemotaxis and invasion attenuating the metastasis in melanoma and breast cancer cell lines. Along the KiSS-1 gene at least 294 SNPs have been described; however the association of these polymorphisms as genetic markers for metastasis in breast cancer studies has not been investigated. Here we describe two simple ...
متن کاملEpigenetic deregulation of TCF21 inhibits metastasis suppressor KISS1 in metastatic melanoma.
Metastatic melanoma is a fatal disease due to the lack of successful therapies and biomarkers for early detection and its incidence has been increasing. Genetic studies have defined recurrent chromosomal aberrations, suggesting the location of either tumor suppressor genes or oncogenes. Transcription factor 21 (TCF21) belongs to the class A of the basic helix-loop-helix family with reported fun...
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ژورنال
عنوان ژورنال: Frontiers in Bioscience
سال: 2006
ISSN: 1093-9946,1093-4715
DOI: 10.2741/1824